Triphosgene → HCID 44218102, compound

HRID 1928733Notes

Reaction equation

HRID 1928733 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH:13]1([N:16]([CH3:20])[CH2:17][CH2:18][NH2:19])[CH2:15][CH2:14]1.[C@H:21]1([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH2:41])[CH:37]=3)[N:32]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1>>[CH:13]1([N:16]([CH3:20])[CH2:17][CH2:18][NH:19][C:1]([NH:41][C:36]2[CH:37]=[C:38]3[C:33](=[CH:34][CH:35]=2)[N:32]=[C:31]([NH:30][C@H:21]2[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:23][CH2:22]2)[CH:40]=[CH:39]3)=[O:12])[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 9989245N-(2-aminoethyl)-N-methylcyclopropanamineHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44218102HCID 44218102, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, N(1)-cyclopropyl-N(1)-methyl-ethane-1,2-diamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=416.6 (M+H+).

Sources & evidence

ORD record
ord-ff60db12b2b2410d8f1b69804b752031
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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