Triphosgene → HCID 86634163, compound

HRID 1928735Notes

Reaction equation

HRID 1928735 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH:13]12[O:20][CH:17]([CH2:18][CH2:19]1)[CH2:16][NH:15][CH2:14]2.[C@H:21]1([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH2:41])[CH:37]=3)[N:32]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1>>[C@H:21]1([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH:41][C:1]([N:15]4[CH2:14][C@H:13]5[O:20][C@H:17]([CH2:18][CH2:19]5)[CH2:16]4)=[O:12])[CH:37]=3)[N:32]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 120692318-Oxa-3-azabicyclo[3.2.1]octaneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 86634163HCID 86634163, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 8-oxa-3-aza-bicyclo[3.2.1]octane and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=415.6 (M+H+).

Sources & evidence

ORD record
ord-6b505687a88a4c438aace932302503d7
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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