Triphosgene → HCID 44218099, compound

HRID 1928736Notes

Reaction equation

HRID 1928736 reaction equation
[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[CH3:13][N:14]1[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]1.[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:23]([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH2:41])[CH:37]=3)[N:32]=2)[CH2:22]1>>[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:23]([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH:41][C:1]([NH:20][CH:17]4[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]4)=[O:2])[CH:37]=3)[N:32]=2)[CH2:22]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 27375314-Amino-1-methylpiperidineHCID 64231785HCID 64231785, compound

Product 1

HCID 44218099HCID 44218099, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-methyl-piperidin-4-ylamine and rac-N2-(2,3-dihydro-benzofuran-3-yl)-quinoline-2,6-diamine; MS: m/e=418.6 (M+H+).

Sources & evidence

ORD record
ord-6ea380321f2b4c0db1480c9f7ff82df2
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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