Triphosgene → HCID 68631824, compound

HRID 1928739Notes

Reaction equation

[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1.[C@H:27]1([NH:36][C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[CH:40][CH:41]=[C:42]([NH2:47])[CH:43]=3)[N:38]=2)[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28]1>>[C:23]([O:22][C:20]([N:17]1[CH2:16][CH2:15][CH:14]([NH:13][C:1]([NH:47][C:42]2[CH:43]=[C:44]3[C:39](=[CH:40][CH:41]=2)[N:38]=[C:37]([NH:36][C@H:27]2[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][CH2:28]2)[CH:46]=[CH:45]3)=[O:12])[CH2:19][CH2:18]1)=[O:21])([CH3:26])([CH3:25])[CH3:24]

Participants

Reactant 3

HCID 94429Triphosgene

HCID 12682914-Amino-1-Boc-piperidine

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 68631824HCID 68631824, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 4-amino-1-tert-butyloxycarbonyl-piperidine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=502.6 (M+H+).

Sources & evidence

ORD record: ord-2b26a00000b94d1eb6be9dbe4eac1a57
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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