Triphosgene → HCID 44217939, compound

HRID 1928742Notes

Reaction equation

HRID 1928742 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.[C@H:23]1([NH:32][C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([NH2:43])[CH:39]=3)[N:34]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1>>[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:1]([NH:43][C:38]3[CH:39]=[C:40]4[C:35](=[CH:36][CH:37]=3)[N:34]=[C:33]([NH:32][C@H:23]3[C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH2:25][CH2:24]3)[CH:42]=[CH:41]4)=[O:12])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 162276441-Cyclopropylpiperidin-4-amineHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44217939HCID 44217939, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-cyclopropyl-piperidin-4-ylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=442.7 (M+H+).

Sources & evidence

ORD record
ord-b811cdd54ce0439986480c3e2db25118
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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