Triphosgene → HCID 44217937, compound

HRID 1928744Notes

Reaction equation

HRID 1928744 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH3:13][O:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19][CH2:18]1.[C@H:24]1([NH:33][C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[C:39]([NH2:44])[CH:40]=3)[N:35]=2)[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25]1>>[C@H:24]1([NH:33][C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[C:39]([NH:44][C:1]([NH:23][CH:20]4[CH2:19][CH2:18][N:17]([CH2:16][CH2:15][O:14][CH3:13])[CH2:22][CH2:21]4)=[O:12])[CH:40]=3)[N:35]=2)[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 201191211-(2-Methoxyethyl)piperidin-4-amineHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44217937HCID 44217937, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(2-methoxy-ethyl)-piperidin-4-ylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=460.7 (M+H+).

Sources & evidence

ORD record
ord-e631e9bdb37e43209e21dc00a0bad92a
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

Loading…