Triphosgene → Rac-1-(1-isopropyl-piperidin-4-yl)-3-[2-(7-methoxy-indan-1-ylamino)-quinolin-6-yl]-urea
Reaction equation
[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[CH:13]([N:16]1[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]1)([CH3:15])[CH3:14].[CH3:23][O:24][C:25]1[CH:26]=[CH:27][CH:28]=[C:29]2[C:33]=1[CH:32]([NH:34][C:35]1[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:45])[CH:41]=3)[N:36]=1)[CH2:31][CH2:30]2>>[CH:13]([N:16]1[CH2:21][CH2:20][CH:19]([NH:22][C:1]([NH:45][C:40]2[CH:41]=[C:42]3[C:37](=[CH:38][CH:39]=2)[N:36]=[C:35]([NH:34][CH:32]2[C:33]4[C:29](=[CH:28][CH:27]=[CH:26][C:25]=4[O:24][CH3:23])[CH2:30][CH2:31]2)[CH:44]=[CH:43]3)=[O:2])[CH2:18][CH2:17]1)([CH3:15])[CH3:14]Participants
4
Procedure
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-isopropyl-piperidin-4-ylamine (CAS no. 127285-08-9) and rac-N2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine (Example 172); MS: m/e=474.7 (M+H+).
Sources & evidence
- ORD record
- ord-1f44cc68e2654ca0a1a69eee10952c80
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08183380B2
Reaction notes
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