HRID1928746

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID94429

Triphosgene

C3Cl6O3

HCID20119121

1-(2-Methoxyethyl)piperidin-4-amine

C8H18N2O

HCID57860964

未命名化合物

PRODUCTS

生成物

结构：COCCN1CCC(NC(=O)Nc2ccc3nc(NC4CCc5cccc(OC)c54)ccc3c2)CC1

HCID44217779

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(2-methoxy-ethyl)-piperidin-4-ylamine and rac-N2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine (Example 172); MS: m/e=490.7 (M+H+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7021e70fc6cd4b8589b423ea1b6deac3
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08183380B2
来源说明: uspto-grants-2012_05

反应 SMILES

[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[CH3:13][O:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19][CH2:18]1.[CH3:24][O:25][C:26]1[CH:27]=[CH:28][CH:29]=[C:30]2[C:34]=1[CH:33]([NH:35][C:36]1[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[C:41]([NH2:46])[CH:42]=3)[N:37]=1)[CH2:32][CH2:31]2>>[CH3:13][O:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([NH:23][C:1]([NH:46][C:41]2[CH:42]=[C:43]3[C:38](=[CH:39][CH:40]=2)[N:37]=[C:36]([NH:35][CH:33]2[C:34]4[C:30](=[CH:29][CH:28]=[CH:27][C:26]=4[O:25][CH3:24])[CH2:31][CH2:32]2)[CH:45]=[CH:44]3)=[O:2])[CH2:21][CH2:22]1