Triphosgene → HCID 44217624, compound

HRID 1928754Notes

Reaction equation

HRID 1928754 reaction equation
[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.[CH3:23][O:24][C:25]1[CH:26]=[CH:27][CH:28]=[C:29]2[C:33]=1[CH:32]([NH:34][C:35]1[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:45])[CH:41]=3)[N:36]=1)[CH2:31][CH2:30]2>>[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:1]([NH:45][C:40]3[CH:41]=[C:42]4[C:37](=[CH:38][CH:39]=3)[N:36]=[C:35]([NH:34][CH:32]3[C:33]5[C:29](=[CH:28][CH:27]=[CH:26][C:25]=5[O:24][CH3:23])[CH2:30][CH2:31]3)[CH:44]=[CH:43]4)=[O:2])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 162276441-Cyclopropylpiperidin-4-amineHCID 57860964Rac-n2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine

Product 1

HCID 44217624HCID 44217624, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-cyclopropyl-piperidin-4-ylamine and rac-N2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine (Example 172); MS: m/e=472.8 (M+H+).

Sources & evidence

ORD record
ord-d9c4ac11c35541d9990feff2162ad617
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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