HRID1928755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID94429

Triphosgene

C3Cl6O3

HCID16227644

1-Cyclopropylpiperidin-4-amine

C8H16N2

HCID57860959

未命名化合物

PRODUCTS

生成物

结构：COc1cccc2c1C(Nc1ccc3cc(NC(=O)NC4CCN(C5CC5)CC4)ccc3n1)CCC2

HCID68638993

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 4-amino-1-cyclopropylpiperidine (CAS no. 62813-02-9) and rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine MS: m/e=486.1 (M+H+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f40e82517fe94207befa952c57aedbc3
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08183380B2
来源说明: uspto-grants-2012_05

反应 SMILES

[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[NH2:13][CH:14]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:22][CH2:21]2)[CH2:16][CH2:15]1.[CH3:23][O:24][C:25]1[CH:26]=[CH:27][CH:28]=[C:29]2[C:34]=1[CH:33]([NH:35][C:36]1[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[C:41]([NH2:46])[CH:42]=3)[N:37]=1)[CH2:32][CH2:31][CH2:30]2>>[CH:20]1([N:17]2[CH2:18][CH2:19][CH:14]([NH:13][C:1]([NH:46][C:41]3[CH:42]=[C:43]4[C:38](=[CH:39][CH:40]=3)[N:37]=[C:36]([NH:35][CH:33]3[C:34]5[C:29](=[CH:28][CH:27]=[CH:26][C:25]=5[O:24][CH3:23])[CH2:30][CH2:31][CH2:32]3)[CH:45]=[CH:44]4)=[O:2])[CH2:15][CH2:16]2)[CH2:22][CH2:21]1