Triphosgene → HCID 44218717, compound

HRID 1928758Notes

Reaction equation

HRID 1928758 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Cl.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21](=[O:24])[CH2:22][F:23])[CH2:17][CH2:16]1.[C@H:25]1([NH:34][C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:45])[CH:41]=3)[N:36]=2)[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1>>[F:23][CH2:22][C:21]([N:18]1[CH2:17][CH2:16][CH:15]([NH:14][C:1]([NH:45][C:40]2[CH:41]=[C:42]3[C:37](=[CH:38][CH:39]=2)[N:36]=[C:35]([NH:34][C@H:25]2[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27][CH2:26]2)[CH:44]=[CH:43]3)=[O:12])[CH2:20][CH2:19]1)=[O:24]

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 68916778HCID 68916778, compound

Product 1

HCID 44218717HCID 44218717, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(4-amino-piperidin-1-yl)-2-fluoro-ethanone hydrochloride and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=462.6 (M+H+).

Sources & evidence

ORD record
ord-f775462a02d24a209a1af8bb2600d2c0
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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