Triphosgene → HCID 44218719, compound

HRID 1928760Notes

Reaction equation

HRID 1928760 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Cl.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH2:17][CH2:16]1.[C@H:27]1([NH:36][C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[CH:40][CH:41]=[C:42]([NH2:47])[CH:43]=3)[N:38]=2)[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28]1>>[C@H:27]1([NH:36][C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[CH:40][CH:41]=[C:42]([NH:47][C:1]([NH:14][CH:15]4[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]([F:26])([F:24])[F:25])[CH2:17][CH2:16]4)=[O:12])[CH:43]=3)[N:38]=2)[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 68639396HCID 68639396, compound

Product 1

HCID 44218719HCID 44218719, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(4-amino-piperidin-1-yl)-3,3,3-trifluoro-propan hydrochloride and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=498.6 (M+H+).

Sources & evidence

ORD record
ord-d980b4449bdc4fb58c290387ee1793a8
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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