Dimethylsulphamoyl chloride → Rac-n'-{2-[(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]quinolin-6-yl}-n,n-dimethylsulfamide

HRID 1928768Notes

Reaction equation

[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[CH3:8][O:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19]=1[CH:18]([NH:20][C:21]1[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([NH2:31])[CH:27]=3)[N:22]=1)[CH2:17][CH2:16][CH2:15]2>>[CH3:8][O:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19]=1[CH:18]([NH:20][C:21]1[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([NH:31][S:3]([N:2]([CH3:7])[CH3:1])(=[O:5])=[O:4])[CH:27]=3)[N:22]=1)[CH2:17][CH2:16][CH2:15]2

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 57860959Rac-n2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine

Product 1

HCID 68640292Rac-n'-{2-[(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]quinolin-6-yl}-n,n-dimethylsulfamide

Procedure

The title compound was prepared in accordance with the general method described in example 66 from dimethylsulfamoyl chloride and rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine; MS: m/e=427.3 (M+H+).

Sources & evidence

ORD record: ord-b945c237676b45d991ef8daff099fe6d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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