(R)-N2-Indan-1-yl-quinoline-2,6-diamine → N-cyclopropyl-N'-{2-[(1R)-2,3-dihydro-1H-inden-1-ylamino]quinolin-6-yl}-N-methylsulfamide

HRID 1928784Notes

Reaction equation

HRID 1928784 reaction equation
FC(F)(F)S([O-])(=O)=O.[CH:9]1([N:12]([CH3:22])[S:13]([N:16]2[CH:20]=[CH:19][N+](C)=C2)(=[O:15])=[O:14])[CH2:11][CH2:10]1.[C@H:23]1([NH:32][C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=C(N)C=3)[N:34]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1>>[CH:9]1([N:12]([CH3:22])[S:13]([NH:16][C:20]2[CH:19]=[C:40]3[C:35](=[CH:36][CH:37]=2)[N:34]=[C:33]([NH:32][C@H:23]2[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:25][CH2:24]2)[CH:42]=[CH:41]3)(=[O:14])=[O:15])[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 866341713-(cyclopropyl-methyl-sulfamoyl)-1-methyl-3-H-imidazol-1-ium trifluoromethanesulfonate

Product 1

HCID 68910936N-cyclopropyl-N'-{2-[(1R)-2,3-dihydro-1H-inden-1-ylamino]quinolin-6-yl}-N-methylsulfamide

Procedure

The title compound was prepared in accordance with step C of the general method described in example 76 from 3-(cyclopropyl-methyl-sulfamoyl)-1-methyl-3-H-imidazol-1-ium trifluoromethanesulfonate and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=409.7 (M+H+).

Sources & evidence

ORD record
ord-d3637ba31445431eb817eaf195b66d83
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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