Triphosgene → HCID 68633185, compound

HRID 1928796Notes

Reaction equation

HRID 1928796 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Cl.[CH3:14][O:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]1)=[O:17].[C@H:25]1([NH:34][C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:45])[CH:41]=3)[N:36]=2)[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1>>[CH3:14][O:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:1]([NH:45][C:40]2[CH:41]=[C:42]3[C:37](=[CH:38][CH:39]=2)[N:36]=[C:35]([NH:34][C@H:25]2[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27][CH2:26]2)[CH:44]=[CH:43]3)=[O:12])[CH2:20][CH2:19]1)=[O:17]

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 53256203Methyl 4-aminopiperidine-1-carboxylate--hydrogen chloride (1/1)HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 68633185HCID 68633185, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 4-amino-piperidine-1-carboxylic acid methyl ester hydrochloride and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=460.8 (M+H−).

Sources & evidence

ORD record
ord-5be8c80b1cdf4f63bf2969681dec6749
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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