Triphosgene → HCID 68632312, compound

HRID 1928798Notes

Reaction equation

HRID 1928798 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([O:12][CH3:13])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[C:20]([NH2:25])[CH:21]=2)[N:16]=1.[C:26](=[O:37])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH3:38][N:39]1[CH2:44][CH2:43][CH:42]([NH2:45])[CH2:41][CH2:40]1>>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([O:12][CH3:13])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[C:20]([NH:25][C:26]([NH:45][CH:42]3[CH2:43][CH2:44][N:39]([CH3:38])[CH2:40][CH2:41]3)=[O:37])[CH:21]=2)[N:16]=1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 27375314-Amino-1-methylpiperidineHCID 68640582HCID 68640582, compound

Product 1

HCID 68632312HCID 68632312, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from rac-N2-(4,6-dichloro-7-methoxy-indan-1-yl)-quinoline-2,6-diamine, bis(trichloromethyl) carbonate and 1-methyl-piperidin-4-ylamine; MS: m/e=515.7 (M+H+).

Sources & evidence

ORD record
ord-7366bacf33d3449aa26d7840b2321c5b
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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