Triphosgene → HCID 44218265, compound

HRID 1928827Notes

Reaction equation

HRID 1928827 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Cl.Cl.[NH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]#[N:24])[CH2:18][CH2:17]1.[C@H:25]1([NH:34][C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([NH2:45])[CH:41]=3)[N:36]=2)[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1>>[C:23]([CH2:22][N:19]1[CH2:20][CH2:21][CH:16]([NH:15][C:1]([NH:45][C:40]2[CH:41]=[C:42]3[C:37](=[CH:38][CH:39]=2)[N:36]=[C:35]([NH:34][C@H:25]2[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27][CH2:26]2)[CH:44]=[CH:43]3)=[O:12])[CH2:17][CH2:18]1)#[N:24]

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 87526708HCID 87526708, compound

Product 1

HCID 44218265HCID 44218265, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, (4-amino-piperidin-1-yl)-acetonitrile dihydrochlorid and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=441.8 (M+H+).

Sources & evidence

ORD record
ord-4ad979859a244e249d38e72be1dd2697
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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