Triphosgene → HCID 44219186, compound

HRID 1928828Notes

Reaction equation

HRID 1928828 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.Cl.[F:14][C:15]([F:25])([F:24])[CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19][CH2:18]1.[C@H:26]1([NH:35][C:36]2[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[C:41]([NH2:46])[CH:42]=3)[N:37]=2)[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27]1>>[C@H:26]1([NH:35][C:36]2[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[C:41]([NH:46][C:1]([NH:23][CH:20]4[CH2:21][CH2:22][N:17]([CH2:16][C:15]([F:14])([F:24])[F:25])[CH2:18][CH2:19]4)=[O:12])[CH:42]=3)[N:37]=2)[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 178400021-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochlorideHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44219186HCID 44219186, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(2,2,2-trifluoro-ethyl)-piperidin-4-ylamine hydrochloride (CAS no: 180869-49-2) and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=484.8 (M+H+).

Sources & evidence

ORD record
ord-6bc4f5ce1ea044ba846c37317bccdc32
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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