Isopropyl isocyanate → Rac-1-[2-(6-fluoro-indan-1-ylamino)-quinolin-6-yl]-3-isopropyl-urea

HRID 1928837Notes

Reaction equation

HRID 1928837 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[NH:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH2:22])[CH:18]=3)[N:13]=2)=[CH:4][CH:3]=1.[CH:23]([N:26]=[C:27]=[O:28])([CH3:25])[CH3:24]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[NH:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:22][C:27]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:28])[CH:18]=3)[N:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 61277Isopropyl isocyanateHCID 68639984Rac-n2-(6-fluoro-indan-1-yl)-quinoline-2,6-diamine

Product 1

HCID 68633958Rac-1-[2-(6-fluoro-indan-1-ylamino)-quinolin-6-yl]-3-isopropyl-urea

Procedure

The title compound was prepared in accordance with the general method described in example 3 from rac-N2-(6-fluoro-indan-1-yl)-quinoline-2,6-diamine and isopropyl isocyanate; MS: m/e=379.4 (M+H+).

Sources & evidence

ORD record
ord-c63676f8eb714830a4bb73a1d47fe44c
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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