Methyl iodide → HCID 178503968, compound

HRID 1928842Notes

Reaction equation

HRID 1928842 reaction equation
[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:21][C:22]([NH2:24])=[S:23])[CH:17]=3)[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH3:25][I:26]>CC(C)=O.O1CCCC1>[IH:26].[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:21][C:22](=[NH:24])[S:23][CH3:25])[CH:17]=3)[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 57860960HCID 57860960, compound

Product 1

HCID 178503968HCID 178503968, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8028TetrahydrofuranSolvent

Procedure

[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-thiourea (600 mg, 1.8 mmol) was dissolved in 20 mL acetone and 10 mL tetrahydrofuran. Methyliodide (306 mg, 2.2 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated and the residue was recrystallized from dichloromethane and diethylether. The title compound (720 mg, 84%) was obtained as a yellow solid; MS: m/e=349.4 (M+H+).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from dichloromethane and diethylether

Sources & evidence

ORD record
ord-7ee94082f72a4fd5bc930788b97aa873
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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