HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1928859Generated: October 31, 2026
Hydroxyamine hydrochloride → 4-Methoxy-benzofuran-3-one oxime
https://huagongshe.com/reaction/1928859
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4-Methoxybenzofuran-3(2H)-one | HCID 639146 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Methoxy-benzofuran-3-one oxime | HCID 86634184 | 100% |
Reaction Steps
A mixture of 4-methoxy-benzofuran-3-one (CAS no: 7169-35-9) (4.9 g, 19 mmol), sodium acetate (3.06 g, 38 mmol) and hydroxylamine hydrochloride (2.58 g, 38 mmol) in ethanol (40 mL) was refluxed for 6 h. Cooled to 23° C., filtered the precipitate off, washed with ethanol and dried in high vacuum to give the title compound as a white solid (5.93 g, 100%); MS: m/e=180.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183380B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-c67408e77a794885b58fd83b94afd5bc |
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| Source note | uspto-grants-2012_05 |
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