(4-Methylpiperazin-1-yl)acetic acid → HCID 68913013, compound

HRID 1928873Notes

Reaction equation

HRID 1928873 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[C:18]([NH2:23])[CH:19]=4)[N:14]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:31][C:32](O)=[O:33])[CH2:27][CH2:26]1>>[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[C:18]([NH:23][C:32](=[O:33])[CH2:31][N:28]5[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]5)[CH:19]=4)[N:14]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 2762732(4-Methylpiperazin-1-yl)acetic acidHCID 68631849HCID 68631849, compound

Product 1

HCID 68913013HCID 68913013, compound

Procedure

The title compound was prepared from rac-N2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-quinoline-2,6-diamine (Example 173) (150 mg, 0.59 mmol) and commercially available (4-methyl-piperazin-1-yl)-acetic acid (77 mg, 0.68 mmol) in accordance with the general method 14 described in example 119 and was obtained as an off-white solid (210 mg, 96%); MS: m/e=448.3 (M+H+).

Sources & evidence

ORD record
ord-e27e9e7947d241f1bb4c28d96b71a57f
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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