(4-Methylpiperazin-1-yl)acetic acid → HCID 68915596, compound

HRID 1928874Notes

Reaction equation

HRID 1928874 reaction equation
[CH2:1]([O:3][C:4]1[C:9]2[CH:10]([NH:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([NH2:24])[CH:20]=4)[N:15]=3)[CH2:11][O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:2].[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33](O)=[O:34])[CH2:28][CH2:27]1>>[CH2:1]([O:3][C:4]1[C:9]2[CH:10]([NH:13][C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([NH:24][C:33](=[O:34])[CH2:32][N:29]5[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]5)[CH:20]=4)[N:15]=3)[CH2:11][O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2762732(4-Methylpiperazin-1-yl)acetic acidHCID 68913590HCID 68913590, compound

Product 1

HCID 68915596HCID 68915596, compound

Procedure

The title compound was prepared from rac-N2-(4-ethoxy-2,3-dihydro-benzofuran-3-yl)-quinoline-2,6-diamine (Example 175) (200 mg, 0.49 mmol) and commercially available (4-methyl-piperazin-1-yl)-acetic acid (74 mg, 0.65 mmol) in accordance with the general method 14 described in example 119 and was obtained as an off-white solid (200 mg, 93%); MS: m/e=462.2 (M+H+).

Sources & evidence

ORD record
ord-789cd6c05a5344f8916a9ec955c1c625
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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