Hydrochloric Acid → 1-[2-((RS)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	1,4-Dioxane	HCID 31275	—
Reactant	1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride	HCID 66841322	—
Reactant	{1-[2-((S)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester	HCID 66841611	—
Product	1-[2-((RS)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride	HCID 66841530	—

It is prepared by BOC-cleavage of tert-butyl ester 11 (1.3 g, 3.99 mmol) with 4M−HCl in dioxane (8 ml, 32 mmol) as described for amine 7.