Hydrochloric Acid → 1-[2-((RS)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride

HRID 1928982Notes

Reaction equation

HRID 1928982 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH3:22])[CH2:10][CH2:9]1)(C)(C)C.[ClH:24].O1CCOCC1.Cl.Cl.Cl.CC1CCN(CCN2CCC(N)CC2)CC1>>[ClH:24].[ClH:24].[ClH:24].[CH3:22][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][N:16]1[CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochlorideHCID 66841611{1-[2-((S)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 668415301-[2-((RS)-2-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride

Procedure

It is prepared by BOC-cleavage of tert-butyl ester 11 (1.3 g, 3.99 mmol) with 4M−HCl in dioxane (8 ml, 32 mmol) as described for amine 7.

Sources & evidence

ORD record
ord-194b6ffe5d5f41a19fdbc0e497e6910c
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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