Hydrochloric Acid → (R)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-piperidin-3-ol tri-hydrochloride

HRID 1928984Notes

Reaction equation

HRID 1928984 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][C@@H:18]([OH:22])[CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:24].O1CCOCC1.Cl.Cl.Cl.CC1CCN(CCN2CCC(N)CC2)CC1>>[ClH:24].[ClH:24].[ClH:24].[NH2:7][CH:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][C@@H:18]([OH:22])[CH2:17]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochlorideHCID 66842084{1-[2-((R)-3-Hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 66841528(R)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-piperidin-3-ol tri-hydrochloride

Procedure

It is prepared by BOC-cleavage of tert-butyl ester 13 (1.7 g, 5.19 mmol) with 4M−HCl in dioxane (10.4 ml, 41.52 mmol) as described for amine 7.

Sources & evidence

ORD record
ord-52e1c638c1a14450b06bda8c9422888c
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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