HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R,4R)-3-methylpiperidin-4-yl pivalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | trans-2,2-Dimethyl-propionic acid 1-benzyl-3-methyl-piperidin-4-yl ester | HCID 131728602 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3R,4R)-3-methylpiperidin-4-yl pivalate | HCID 59600263 | — |
Reaction Steps
The trans-ester 18 (104 g, 359 mmol) is hydrogenated in methanol (1700 ml) with Pd/C in the presence of one equivalent of HCl (431 ml, 359 mmol, 1.25M in MeOH). The mixture is filtered and evaporated. The residue is redissolved in ether and extracted with 1N-NaOH and brine. Evaporation gives a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3be307865666433cb8f3d30bfa591a17 |
| Source note | uspto-grants-2012_05 |