反应详情

Racemic 19 (62.7 g, 314.4 mmol) is dissolved in EtOAc (300 ml) and a solution of L-(−)-0,0′-Dibenzoyl tartaric acid (56.3 g, 157.2 mmol) in EtOAc (450 ml) is added. The formed solid is filtered off, washed with cold EtOAc and dried. It is then re-crystallized from hot methanol (400 ml). The crystals are collected and the free base is liberated by treatment with 1N-NaOH and extraction with ether.

1. filtrationThe formed solid is filtered off
2. washwashed with cold EtOAc
3. customdried
4. customIt is then re-crystallized from hot methanol (400 ml)
5. customThe crystals are collected
6. extractionthe free base is liberated by treatment with 1N-NaOH and extraction with ether