HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {1-[2-(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester | HCID 66841981 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride | HCID 66841574 | — |
Reaction Steps
Ester 26 (4.5 g, 12.73 mmol) is dissolved in 4M HCl in dioxane at 0° C. and stirred at room temperature for 3 hours. After evaporation of the solvent the product is dried at high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3148fcc83d494fcbb79f5747888a0944 |
| Source note | uspto-grants-2012_05 |