Hydrochloric Acid → 8-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride

HRID 1928995Notes

Reaction equation

HRID 1928995 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH:21]3[CH2:22][CH2:23][CH:17]2[CH2:18][CH:19]([OH:24])[CH2:20]3)[CH2:10][CH2:9]1)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[ClH:26].[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH:17]3[CH2:23][CH2:22][CH:21]2[CH2:20][CH:19]([OH:24])[CH2:18]3)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66841981{1-[2-(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 668415748-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Ester 26 (4.5 g, 12.73 mmol) is dissolved in 4M HCl in dioxane at 0° C. and stirred at room temperature for 3 hours. After evaporation of the solvent the product is dried at high vacuum.

Workup

  1. customAfter evaporation of the solvent the product
  2. customis dried at high vacuum

Sources & evidence

ORD record
ord-3148fcc83d494fcbb79f5747888a0944
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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