1-Benzyl-3,5-dimethylpiperidin-4-one → 1-Benzyl-3,5-dimethylpiperidin-4-ol

HRID 1929003Notes

Reaction equation

HRID 1929003 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]([CH3:14])[C:11](=[O:15])[CH:10]([CH3:16])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[CH2:1]([N:8]1[CH2:13][CH:12]([CH3:14])[CH:11]([OH:15])[CH:10]([CH3:16])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 222789201-Benzyl-3,5-dimethylpiperidin-4-one

Product 1

HCID 230036661-Benzyl-3,5-dimethylpiperidin-4-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodiumboronhydride (121 mg, 3.2 mmol) is added to a solution of 44 (1.4 g, 6.4 mmol) in 15 ml of methanol and the mixture is stirred at room temperature for 30 min. The mixture is evaporated, and the residue is dissolved in ethyl acetate and washed with water.

Workup

  1. customThe mixture is evaporated
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. washwashed with water

Sources & evidence

ORD record
ord-256fbf3064dd4b13b57874ec3c1fbcf9
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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