反应详情

A solution of piperidine 51 (35.99 g, 130.7 mmol) in methanol is hydrogenated with Pd/C in the presence of one equivalent of HCl (104.5 ml, 130.7 mmol, 1.25M in MeOH). After filtration and evaporation, the crude is taken up in ether and washed with 1N-NaOH and brine. Drying, evaporation and distillation (0.08 mbar, 75-90 C) gave a colourless oil. Yield: 17.98 g (74%).

1. filtrationAfter filtration and evaporation
2. washwashed with 1N-NaOH and brine
3. customDrying
4. customevaporation and distillation (0.08 mbar, 75-90 C)
5. customgave a colourless oil