HCID 59600181, compound → 4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[2-(3-(R)-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 1929051Notes

Reaction equation

HRID 1929051 reaction equation
[N:1]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH2:29][CH:30]3[CH2:33][CH2:32][CH2:31]3)[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6]C[CH2:4][CH2:3][CH2:2]1.Cl.Cl.Cl.NC1CCN(CCN2C3CCC2CC([OH:54])C3)CC1>>[OH:54][C@@H:3]1[CH2:4][CH2:6][CH2:7][N:1]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH2:29][CH:30]3[CH2:33][CH2:32][CH2:31]3)[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:2]1

Participants

3

Reactant 2

HCID 59600181HCID 59600181, compoundHCID 668415748-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride

Product 1

HCID 596001314-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[2-(3-(R)-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid 82 (preparation see Example 22) and amine 24.

Sources & evidence

ORD record
ord-6cf68b6ab89b45ff9a294c5a98b111ee
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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