4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid → 4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 1929052Notes

Reaction equation

HRID 1929052 reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=O)[NH:11]3)[CH2:4][CH2:3][CH2:2]1.Cl.Cl.Cl.[NH2:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:29][C@@H:30]([N:32]2[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34][CH2:33]2)[CH3:31])[CH2:25][CH2:24]1>>[OH:38][CH:35]1[CH2:34][CH2:33][N:32]([C@@H:30]([CH3:31])[CH2:29][N:26]2[CH2:25][CH2:24][CH:23]([NH:22][C:16]([C:10]3[NH:11][C:12]4[C:8]([CH:9]=3)=[C:7]([O:6][CH2:5][CH:1]3[CH2:2][CH2:3][CH2:4]3)[CH:15]=[CH:14][CH:13]=4)=[O:18])[CH2:28][CH2:27]2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 591526824-Cyclobutylmethoxy-1H-indole-2-carboxylic acidHCID 66841433HCID 66841433, compound

Product 1

HCID 596002114-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-cyclobutylmethoxy-1H-indole-2-carboxylic acid, 82 (see example 22) and amine 50.

Sources & evidence

ORD record
ord-4bf7b43f64e640a5b81ad22decb5015a
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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