4-(3,3-dimethyl-butoxy)-1H-indole-2-carboxylic acid → 4-(3,3-Dimethyl-butoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

HRID 1929065Notes

Reaction equation

HRID 1929065 reaction equation
[CH3:1][C:2]([CH3:19])([CH3:18])[CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[C:9]([C:15]([OH:17])=O)[NH:10]2.[ClH:20].Cl.Cl.[NH2:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34][CH2:33]2)[CH2:26][CH2:25]1>>[ClH:20].[ClH:20].[OH:38][CH:35]1[CH2:34][CH2:33][N:32]([CH2:31][CH2:30][N:27]2[CH2:26][CH2:25][CH:24]([NH:23][C:15]([C:9]3[NH:10][C:11]4[C:7]([CH:8]=3)=[C:6]([O:5][CH2:4][CH2:3][C:2]([CH3:1])([CH3:19])[CH3:18])[CH:14]=[CH:13][CH:12]=4)=[O:17])[CH2:29][CH2:28]2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 668415724-(3,3-dimethyl-butoxy)-1H-indole-2-carboxylic acidHCID 66841786HCID 66841786, compound

Product 1

HCID 668413154-(3,3-Dimethyl-butoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized analogously to Example 1 from 4-(3,3-dimethyl-butoxy)-1H-indole-2-carboxylic acid (92) (preparation see below) and amine 21.

Sources & evidence

ORD record
ord-055b7c1b1ace4f0b985bf5197a12eb40
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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