反应详情

温度

0 °C

1M LiAlH4-solution in THF (75.9 ml, 75.9 mmol) is diluted with 100 ml of THF and cooled to 0° C. 110 (7.9 g, 37.9 mmol) is dissolved in 100 ml of THF and added dropwise within 30 min. After completed addition the mixture is allowed to stir at rt for 2 h. Then the reaction mixture is cooled to −15° C. and 10 ml of a 1M NaOH solution is added very slowly. The mixture is filtrated over celite and evaporation under reduced pressure gave 5.3 g of a yellow oil.

1. additionadded dropwise within 30 min
2. additionaddition the mixture
3. temperatureThen the reaction mixture is cooled to −15° C.
4. filtrationThe mixture is filtrated over celite and evaporation under reduced pressure