HCID 66841531, compound → 4-(6-Fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

HRID 1929099Notes

Reaction equation

HRID 1929099 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]2[C:6]([CH2:9][O:10][C:11]3[CH:19]=[CH:18][CH:17]=[C:16]4[C:12]=3[CH:13]=[C:14]([C:20]([OH:22])=O)[NH:15]4)=[CH:7][O:8][C:4]=2[CH:3]=1.[ClH:25].Cl.Cl.[NH2:28][CH:29]1[CH2:34][CH2:33][N:32]([CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][CH:40]([OH:43])[CH2:39][CH2:38]2)[CH2:31][CH2:30]1>>[ClH:25].[ClH:25].[OH:43][CH:40]1[CH2:39][CH2:38][N:37]([CH2:36][CH2:35][N:32]2[CH2:31][CH2:30][CH:29]([NH:28][C:20]([C:14]3[NH:15][C:16]4[C:12]([CH:13]=3)=[C:11]([O:10][CH2:9][C:6]3[C:5]5[CH:23]=[CH:24][C:2]([F:1])=[CH:3][C:4]=5[O:8][CH:7]=3)[CH:19]=[CH:18][CH:17]=4)=[O:22])[CH2:34][CH2:33]2)[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 66841531HCID 66841531, compoundHCID 66841786HCID 66841786, compound

Product 1

HCID 668415434-(6-Fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized from 4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (106, see example 55) and amine 21 analogously to the method described in example 1.

Sources & evidence

ORD record
ord-1efb459801a7489da26c131f115bf3ee
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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