HCID 66841433, compound → 4-(4-Ethoxy-phenyl)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 1929152Notes

Reaction equation

HRID 1929152 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[CH:12]=[C:13]([C:19](O)=[O:20])[NH:14]3)=[CH:6][CH:5]=1)[CH3:2].Cl.Cl.Cl.[NH2:25][CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][C@@H:33]([N:35]2[CH2:40][CH2:39][CH:38]([OH:41])[CH2:37][CH2:36]2)[CH3:34])[CH2:28][CH2:27]1>>[OH:41][CH:38]1[CH2:37][CH2:36][N:35]([C@@H:33]([CH3:34])[CH2:32][N:29]2[CH2:28][CH2:27][CH:26]([NH:25][C:19]([C:13]3[NH:14][C:15]4[C:11]([CH:12]=3)=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=3)[CH:18]=[CH:17][CH:16]=4)=[O:20])[CH2:31][CH2:30]2)[CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 66841433HCID 66841433, compoundHCID 668414354-(4-ethoxy-phenyl)-1H-indole-2-carboxylic acid

Product 1

HCID 596002384-(4-Ethoxy-phenyl)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(4-ethoxy-phenyl)-1H-indole-2-carboxylic acid, (preparation analogously to 128, see example 141) and amine 50.

Workup

  1. custom(preparation analogously to 128

Sources & evidence

ORD record
ord-6cefe4df3ea34972903a6a62293c8572
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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