HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 66841667, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-(4-Fluoro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66841591 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 66841667 | HCID 66841667 | — |
Reaction Steps
148 (510 mg, 1.7 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (82 mg, 3.4 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6398294fab3c422eb0c8a79bc71023e6 |
| Source note | uspto-grants-2012_05 |