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148 (510 mg, 1.7 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (82 mg, 3.4 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.

1. customAfter evaporation
2. customis acidified at 0° C. with 2M HCl
3. extractionextracted with ethyl acetate
4. dry with materialThe organic layers are dried over sodium sulphate
5. customevaporated