Hydrochloric Acid → 2-(4-Aminopiperidin-1-yl)ethan-1-ol

HRID 1929217Notes

Reaction equation

HRID 1929217 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][OH:16])[CH2:10][CH2:9]1)(C)(C)C.Cl.O1CCOCC1>>[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][OH:16])[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 45076484[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 157334452-(4-Aminopiperidin-1-yl)ethan-1-ol

Procedure

Compound 191 (4.02 g, 16.46 mmol) are treated with 4M HCl in dioxane (60 ml, 240 mmol) and the mixture is stirred at room temperature for 1 h. The white precipitate is filtered off, washed with ether and dried under high vacuum. The mother liquor is concentrated and treated with ether. The white solid is filtered off and dried under high vacuum.

Workup

  1. filtrationThe white precipitate is filtered off
  2. washwashed with ether
  3. customdried under high vacuum
  4. concentrationThe mother liquor is concentrated
  5. additiontreated with ether
  6. filtrationThe white solid is filtered off
  7. customdried under high vacuum

Sources & evidence

ORD record
ord-e21b05e5668a470f851d64c7c88830b0
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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