4-Isobutoxy-benzo[b]thiophene-2-carboxylic acid → 4-Isobutoxy-benzo[b]thiophene-2-carboxylic acid [1-(2-piperidin-1-yl-ethyl)-piperidin-4-y]-amide

HRID 1929239Notes

Reaction equation

HRID 1929239 reaction equation
[CH2:1]([O:5][C:6]1[C:14]2[CH:13]=[C:12]([C:15]([OH:17])=O)[S:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3].Cl.Cl.Cl.[N:21]1([CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:27][CH2:28][N:29]2[CH2:30][CH2:31][CH:32]([NH:35][C:15]([C:12]3[S:11][C:10]4[CH:9]=[CH:8][CH:7]=[C:6]([O:5][CH2:1][CH:2]([CH3:3])[CH3:4])[C:14]=4[CH:13]=3)=[O:17])[CH2:33][CH2:34]2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 596002594-Isobutoxy-benzo[b]thiophene-2-carboxylic acidHCID 668413621-(2-(Piperidin-1-yl)ethyl)piperidin-4-amine trihydrochloride

Product 1

HCID 596001964-Isobutoxy-benzo[b]thiophene-2-carboxylic acid [1-(2-piperidin-1-yl-ethyl)-piperidin-4-y]-amide

Procedure

This compound is synthesized from compound 202 and amine 1 analogously to the method described in Example 178.

Sources & evidence

ORD record
ord-12e617cbb9e242dabad7a47ce3bb6078
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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