Ethanol → 4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

HRID 1929242Notes

Reaction equation

HRID 1929242 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:23][C@@H:24]4[CH2:28][CH2:27][O:26][CH2:25]4)=[C:17]([N+:20]([O-])=O)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].C(O)C.O>[Fe].C(O)(=O)C>[NH2:20][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][C:16]=1[O:23][C@@H:24]1[CH2:28][CH2:27][O:26][CH2:25]1)[N:13]=[CH:12][N:11]=[C:10]2[NH:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 962WaterHCID 669368164-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

Product 1

HCID 669364864,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3R)-tetrahydro-3-furanyl]oxy]-

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 12.80 g of 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-((R)-tetrahydrofuran-3-yloxy)quinazoline, 200 ml of ethanol, 100 ml of water, and 17.20 ml of glacial acetic acid is heated to reflux temperature. Then a total of 7.00 g of iron powder is added in batches. The reaction mixture is refluxed for about four hours and then cooled to ambient temperature overnight. For working up, the reaction mixture is evaporated using the rotary evaporator. The residue is taken up in methylene chloride/methanol (9:1), mixed with 20 ml of concentrated ammonia solution and filtered through a layer of silica gel. It is washed with copious amounts of methylene chloride/methanol (9:1) and the combined filtrates are evaporated down. The residue is stirred with diethylether and suction filtered. Yield: 8.59 g (73% of theory); mass spectrum (ESI−): m/z=373, 375 [M−H]−; Rf value: 0.27 (silica gel, ethyl acetate/methanol=9:1).

Workup

  1. temperatureis heated
  2. temperatureto reflux temperature
  3. temperatureThe reaction mixture is refluxed for about four hours
  4. customthe reaction mixture is evaporated
  5. customthe rotary evaporator
  6. additionmixed with 20 ml of concentrated ammonia solution
  7. filtrationfiltered through a layer of silica gel
  8. washIt is washed with copious amounts of methylene chloride/methanol (9:1)
  9. customthe combined filtrates are evaporated down
  10. filtrationfiltered

Sources & evidence

ORD record
ord-de015d718aaa420e876ded7f765af087
Source dataset
uspto-grants-2012_05
Patent number
USRE043431E1

Reaction notes

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