Trifluoroacetic acid → HCID 66864246, compound

HRID 1929277Notes

Reaction equation

HRID 1929277 reaction equation
FC(F)(F)C(O)=O.C(OC(=O)[CH:14]([C:20](=[O:37])[C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[C:23]([NH:31][CH3:32])[C:22]=1[S:33]([CH3:36])(=[O:35])=[O:34])[C:15]([CH:17]1[CH2:19][CH2:18]1)=[O:16])(C)(C)C>C(Cl)Cl>[CH:17]1([C:15](=[O:16])[CH2:14][C:20]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:28])[F:30])=[C:23]([NH:31][CH3:32])[C:22]=2[S:33]([CH3:36])(=[O:34])=[O:35])=[O:37])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66864936HCID 66864936, compound

Product 1

HCID 66864246HCID 66864246, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.0 ml of trifluoroacetic acid were heated at 55°-60° C. A solution of 5.3 g (8.0 mmol; 70% purity) of tert-butyl-3-cyclopropyl-2-(3-methylamino-2-methylsulfonyl-4-trifluoromethylbenzoyl)-3-oxopropanoate in 10 ml of CH2Cl2 was added dropwise and the mixture was then heated at reflux for 15 min. The solvent was removed in vacuo and the residue was purified by column chromatography on silica gel. This gave 1.22 g of product in 95% purity.

Workup

  1. temperaturethe mixture was then heated
  2. temperatureat reflux for 15 min
  3. customThe solvent was removed in vacuo
  4. customthe residue was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-88cf961bc33d4d428292844a3e39c37d
Source dataset
uspto-grants-2012_05
Patent number
US08188009B2

Reaction notes

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