Dimethylformamide dimethyl acetal → HCID 66864813, compound

HRID 1929278Notes

Reaction equation

HRID 1929278 reaction equation
[CH:1]1([C:4](=[O:24])[CH2:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([NH:18][CH3:19])[C:9]=2[S:20]([CH3:23])(=[O:22])=[O:21])=[O:7])[CH2:3][CH2:2]1.CO[CH:27](OC)[N:28]([CH3:30])[CH3:29]>CCCCCCC>[CH:1]1([C:4](=[O:24])[C:5](=[CH:27][N:28]([CH3:30])[CH3:29])[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:17])[F:16])=[C:10]([NH:18][CH3:19])[C:9]=2[S:20]([CH3:23])(=[O:21])=[O:22])=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 66864246HCID 66864246, compound

Product 1

HCID 66864813HCID 66864813, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

1.22 g (3.4 mmol) of 1-cyclopropyl-3-(3-methylamino-2-methylsulfonyl-4-trifluoromethylphenyl)propane-1,3-dione were treated with 3.0 ml (22.7 mmol) of N,N-dimethyl formamide dimethyl acetal and the mixture was stirred for 16 h at RT. Then, a little n-heptane was added, and the contents were stirred for a further 10 min at RT. The precipitate was filtered off with suction. This gave 1.29 g of product in 95% purity.

Workup

  1. stirringthe contents were stirred for a further 10 min at RT
  2. filtrationThe precipitate was filtered off with suction

Sources & evidence

ORD record
ord-f9d187ea10c04a19b71ad88a64e097ee
Source dataset
uspto-grants-2012_05
Patent number
US08188009B2

Reaction notes

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