1,1'-Thiocarbonyldiimidazole → HCID 59550995, compound

HRID 1929321Notes

Reaction equation

HRID 1929321 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[S:17]>ClCCl>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N:15]=[C:16]=[S:17])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 59551030HCID 59551030, compound

Product 1

HCID 59550995HCID 59550995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-isopropyl-7-methoxy-1H-indol-4-ylamine (U) (1 eq) in dichloromethane was added 1,1′-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

Workup

  1. customthen evaporated to dryness
  2. customFurther purification by column chromatography

Sources & evidence

ORD record
ord-65452fc5cba84c1fa7d1f4b63eb2f752
Source dataset
uspto-grants-2012_05
Patent number
US08188075B2

Reaction notes

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