1,2,4-Trichloro-3-[1-(2-fluoro-4-nitrophenoxy)ethyl]benzene → 3-Fluoro-4-[1-(2,3,6-trichlorophenyl)ethoxy]aniline

HRID 1929353Notes

Reaction equation

HRID 1929353 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:13]=2[F:21])[CH3:10])[C:3]=1[Cl:22]>CO.[Pt]=O>[F:21][C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][C:12]=1[O:11][CH:9]([C:4]1[C:5]([Cl:8])=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[Cl:22])[CH3:10])[NH2:18]

Participants

4

Reactant 1

HCID 685114401,2,4-Trichloro-3-[1-(2-fluoro-4-nitrophenoxy)ethyl]benzene

Product 1

HCID 685123003-Fluoro-4-[1-(2,3,6-trichlorophenyl)ethoxy]aniline

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

3-Fluoro-4-[1-(2,3,6-trichlorophenyl)ethoxy]aniline was prepared according to the method described in Example 20e but from 0.093 g of platinum oxide and 1.5 g of 1,2,4-trichloro-3-[1-(2-fluoro-4-nitrophenoxy)ethyl]benzene in 100 cm3 of methanol.

Sources & evidence

ORD record
ord-3214bedd94774c1ebe5e02e2d4171ed2
Source dataset
uspto-grants-2012_05
Patent number
US08188078B2

Reaction notes

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