p-Fluoronitrobenzene → HCID 68513655, compound

HRID 1929356Notes

Reaction equation

HRID 1929356 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:5]=1[CH:11]([OH:14])[CH2:12][CH3:13].F[C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1>>[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:5]=1[CH:11]([O:14][C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1)[CH2:12][CH3:13]

Participants

4

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 24758Sodium hydrideHCID 12105278HCID 12105278, compound

Product 1

HCID 68513655HCID 68513655, compound

Procedure

1,3-Dichloro-2-[1-(4-nitrophenoxy)propyl]benzene was prepared according to the method described in Example 20f but from 0.236 g of sodium hydride (at 60% in the oil), 1.1 g of 1-(2,6-dichlorophenyl)propan-1-ol and 0.832 g of 1-fluoro-4-nitrobenzene. We thus obtain 1.18 g of 1,3-dichloro-2-[1-(4-nitrophenoxy)propyl]benzene in the form of a colorless oil which crystallizes, having the following characteristics:

Workup

  1. customWe thus obtain 1.18 g of 1,3-dichloro-2-[1-(4-nitrophenoxy)propyl]benzene in the form of a colorless oil which crystallizes

Sources & evidence

ORD record
ord-6a5aff6908074cf9b74cb2b6b9b757b7
Source dataset
uspto-grants-2012_05
Patent number
US08188078B2

Reaction notes

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