Benzophenone imine → HCID 58155237, compound

HRID 1929473Notes

Reaction equation

HRID 1929473 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C:8]2([CH:15]3[CH2:17][CH2:16]3)[NH:13][C:12](=[O:14])[CH2:11][O:10][CH2:9]2)[CH:7]=1.[C:19](=[NH:32])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>[Pd]>[C:19](=[N:32][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C:8]2([CH:15]3[CH2:17][CH2:16]3)[NH:13][C:12](=[O:14])[CH2:11][O:10][CH2:9]2)[CH:7]=1)([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 136809Benzophenone imineHCID 58155298HCID 58155298, compound

Product 1

HCID 58155237HCID 58155237, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In an analogous manner to that described for the preparation of Building block A [f)], the palladium-catalyzed amination of (RS)-5-(5-bromo-2-fluoro-phenyl)-5-cyclopropyl-morpholin-3-one with benzophenonimine yielded the (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-cyclopropyl-morpholin-3-one as a yellow foam. Mass (calculated) C26H23FN2O2 [414.478]; (found) [M+H]+=415.

Sources & evidence

ORD record
ord-a09eb102d4b04d0d86b7fa92a5e30ff5
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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