Hydrochloric Acid → HCID 58155227, compound

HRID 1929494Notes

Reaction equation

HRID 1929494 reaction equation
C(=[N:14][C:15]1[CH:16]=[C:17]([C@@:21]2([CH3:30])[NH:26][C:25](=[S:27])[C:24]([CH3:29])([CH3:28])[O:23][CH2:22]2)[CH:18]=[CH:19][CH:20]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl>>[NH2:14][C:15]1[CH:16]=[C:17]([C@@:21]2([CH3:30])[NH:26][C:25](=[S:27])[C:24]([CH3:29])([CH3:28])[O:23][CH2:22]2)[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58155194HCID 58155194, compound

Product 1

HCID 58155227HCID 58155227, compound

Procedure

In analogy to step h) in the synthesis of Building block K, the hydrolysis of (R)-5-[3-(benzhydrylidene-amino)-phenyl]-2,2,5-trimethyl-morpholin-3-thione with hydrochloric acid yielded the title compound (Building block L) as an off-white solid (86% of theory). Mass (calculated) C13H18N2OS [250.37]; (found) [M+H]+=251.

Workup

  1. customIn analogy to step h) in the synthesis of Building block K

Sources & evidence

ORD record
ord-469b0c99462147929eb1b887f6c25f00
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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